Home » Research & Innovation » Clinical Trials

Research Studies

College of Health Sciences researchers are currently enrolling participants in studies focused on Parkinson’s, blood vessel function, strokecerebral palsy, hamstring injury, chronic kidney disease, and Achilles injuries — just to name a few. We are always looking for community members to participate.

Please scroll down to view study descriptions. Each study has specific inclusion/exclusion criteria. Many studies are seeking healthy control participants.

Studies Currently Enrolling Participants

Dietary Potassium


Study – Dietary Potassium
Title The Vascular of Effects of Dietary Potassium on Humans
Recruitment Liza Walker | 302-831-3181 |

The Cardiovascular Nutrition Research Laboratory is seeking volunteer participants for a research study examining the effects of dietary potassium and salt. The first visit is a screening session to determine if you qualify for participation. Admitted participants will begin a three week controlled diet (food provided), and attend weekly data collection sessions. These sessions will last approximately 4.5 hours.

As part of study participation, subjects will have their blood pressure and ECG evaluated and will be provided with 3 weeks of meals. Participants will also be compensated for their time.

Inclusion Criteria You may be eligible to participate if you are between the ages of 22 and 45 years old, have normal blood pressure, non-smoker and in reasonably good health.
Achilles Tendon


Study – Achilles Tendon I
Title Achilles Tendon Study
Recruitment Jean Marmon | 302-831-4615 |
Criteria We are looking for individuals 16 years or older (no upper age limit) who have an Achilles tendon injury (including tendinitis, tendinosis, tendinopathy, rupture, bursitis and insertional disorders). We are also looking for healthy individuals 18 years or older who are interested in participating in research studies.


Study – Achilles Tendon II
Title Achilles Tendon Rupture Study
Recruitment Karin Gravare-Silbernagel | 302-831-4808 |
Criteria We are currently recruiting people with recent Achilles tendon rupture for an observational study to better understand tendon recovery.
Ankle Prosthesis


Study – Ankle Prosthesis
Title Ankle Prosthesis (powered and non-powered)
Recruitment Caitlin Mahon | 301-400-2093 |

The purpose of the study is to learn if there are differences between a powered ankle prosthesis and the unpowered prosthesis you currently wear. We will look at differences in how you walk in both prostheses, if one allows you to use less energy when you walk, and if one allows you to participate in and perform more activities than the other. There is no guarantee that you will benefit from this study, however other research studies have shown that the use of a powered ankle prosthesis may decrease the stress on your un-amputated leg and may reduce the energy you require to complete daily tasks.


ACL injuries
Study – ACL injuries
Title Can Neuromuscular Training Alter Movement Patterns
Recruitment Recruiting (Lynn Snyder-Mackler)
Study Results No Results Available
Conditions Acute Injury of Anterior Cruciate Ligament
Interventions Other: Perturbation
Antioxidant Cocktails


Title Antioxidant Cocktails
Recruitment Alexis Mbakwe: or 302-831-3973
Description The Cardiovascular Physiology lab needs volunteer participants for a research study examining how blood vessel function is affected when consuming an antioxidant cocktail (Vitamin C, Vitamin E and Alpha-Lipoic Acid) before a high salt meal. You may be eligible to participate if you are between the ages of 18-45 years of age, have normal blood pressure, have no history of heart disease, kidney disease or diabetes, maintain a normal weight and do not use tobacco. Participants will be compensated for their time.
Arthritis - Knee
Study – Arthritis – Knee
Title Electrical Stimulation After Total Knee Arthroplasty
Recruitment Recruiting (Lynn Snyder-Mackler)
Study Results No Results Available
Conditions Total Knee Arthroplasty|Osteoarthritis
Interventions Procedure: Neuromuscular electrical stimulation|Procedure: Voluntary exercise


Study – Arthrogryposis I
Title Playskin Lift Exoskeletal Garment for Children with Arm Movement Impairments
Recruitment Recruiting (Iryna Babik)
Description Study will track the effects of an exoskeletal garment, the Playskin Lift. The garment is a soft, comfortable onesie or shirt with springy inserts under each arm to help children with weakness lift their arms to move and play. We are looking for families to work with us to test the immediate and longer-term effects of the garment as well as to improve and enhance the garment.
Inclusion criteria Children with arthrogryposis affecting the arms who are under 3 years of age


Study – Arthrogryposis II
Title Intervention with the Playskin Lift for Kids with Arthrogryposis
Recruitment Recruiting (Michele Lobo)
Description Investigate the effectiveness of the Playskin Lift soft exoskeletal garment to improve children’s ability to reach and manipulate objects.
Inclusion criteria Children with arthrogryposis (AMC), age range 0-4 years, having good head and trunk control and reasonably good vision that would allow the child to see toys
Autism Spectrum Disorder


Study – Autism Spectrum Disorder
Title Adult Needs Assessment Study
Recruitment Recruiting (Anjana Bhat)
Description You are invited to participate in a research study that examines the strengths and needs of adolescents and adults with Autism Spectrum Disorder.
Who can participate Adolescents and adults with and without Autism Spectrum Disorder between 13 and 50 years of age
What will be involved
  • This study will involve 2 testing visits where we will ask you to visit the lab or we will visit you at your home or school/college or day-care facility. The first testing session will last for 2 hours and the second session will last for 1.5 hours.
  • Prior to participation in the study, individuals with autism will need to provide a letter from a pediatrician, clinical psychologist, or psychiatrist confirming autism diagnosis.
  • During the first session, we will ask you or your caregiver to fill our standardized questionnaires that will assess your movement and social interaction skills as well as your ability to participate in activities within the community.
  • During the second testing session, we will conduct tests that will assess your movement skills and physical fitness levels. Both testing sessions will be videotaped so that we can score the tests later.
  • During the first testing visit, we will also provide you with an activity monitor in the form of wristwatch and ask you to wear this watch for the next 1 week. This monitor will help us assess your physical activity levels over a week’s time.
  • You will receive $20 as payment for participation.
Cerebral Palsy
Cerebral Palsy
Title Effect of Botox and Vibration on Bone in Children With Cerebral Palsy
Recruitment Recruiting (Chris Modlesky)
Study Results No Results Available
Conditions Cerebral Palsy | Muscle Spasticity
Interventions Device: High-frequency, low magnitude vibration plate
Other: No vibration plate


Children with Hemiplegia
Study – Hemiplegia
Title Playskin Duo Garment to Encourage Play with Two Hands for Children with Movement Impairments in One Arm
Recruitment Recruiting (Michele Lobo)
Description We are testing the effects of daily play using the Playskin Duo, a soft garment that allows for the provision of adjustable levels of resistance to be provided to the unaffected arm of children with hemiplegia. We are aiming to combat the developmental neglect and disuse that often emerges in children with hemiplegia. Because one arm is so easy for them to use, they learn to perform most tasks with only that arm while the affected arm grows weaker and harder to move and control over time. The Playskin Duo aims to level the playing field, making it just a bit harder to move the “good” arm to encourage children to do more with the affected arm and with both hands. We believe this intervention is a child- and family-friendly alternative to treatments like casting of the “good” arm or interventions that require travel and high costs for intensive therapy programs. We are testing whether shorter bouts of intervention daily with the Playskin Duo at home, at school, wherever kids go, can effectively improve arm function when the garment is off.
Chronic Kidney Disease


Study – Chronic Kidney Disease
Title Exercise and Vascular Health in Chronic Kidney Disease
Recruitment Recruiting (Danielle Kirkman)

This study investigates:

a) The causes of poor blood vessel health in Chronic Kidney Disease

b) The effect of regular exercise on the health of blood vessels to reduce the very high risk of cardiovascular disease in Chronic Kidney Disease Patients.

On completion of the study, participants will be compensated $75.00 for their time and travel.


This study is recruiting both chronic kidney disease patients as well as healthy individuals to act as a comparison.

For healthy individuals, participation in the study involves 3 visits to the Vascular Physiology Lab. Participant must be healthy, non-smokers.

For CKD patients, participation in the study will involve 6 visits to the lab and 12 weeks of supervised exercise tailored to each individual. Participants must be stage 3 to 5 chronic kidney disease; no history of cardiovascular disease; no current tobacco use. On completion of the study, participants will be compensated $150.00 for their time and travel.

Study II – Chronic Kidney Disease
Title Mitochondria Health and Vascular Function in Chronic Kidney Disease
Recruitment Recruiting (Danielle Kirkman)
Description Research in the Vascular Physiology Lab aims to investigate the causes of poor blood vessel health in Chronic Kidney Disease patients in order to reduce the high cardiovascular disease burden in this patient population. The purpose of this study is to investigate the role of the mitochondrial oxidative stress in blood vessel health in chronic kidney disease patients. Participation in the study will involve a total of 5 visits to the lab and a 4 week intervention period whereby the participant will take a daily mitochondria targeted antioxidant supplement or a placebo. On completion of the study participant will be compensated $100 for their time and travel. 
High Blood Pressure
High Blood Pressure
Title Exercise and Vascular Function in Chronic Kidney Disease
Recruitment Recruiting (Dave Edwards)
Study Results No Results Available
Conditions Chronic Renal Insufficiency
Interventions Other: Aerobic Exercise Training
How Eating Impacts Daily Routines


Title Timing of Energy Consumption on the Circadian Timing System in Children
Recruitment Recruiting (Amanda Kopetsky)
Description This study is looking for children who are ≥85th percentile for body mass index for age, to participate in a 5 week study to help us understand how timing of eating impacts daily routines. Participants can be compensated up to $135 for their time.
Low Back and Radicular Leg Pain


Study – Low Back and Radicular Leg Pain
Title Cardiovascular health status in older adults with low back and radicular leg pain
Recruitment Recruiting (Victoria Allen)
Criteria Delaware Spine Studies is seeking volunteers (60-85 years old) to participate in a research study that will help determine the cardiovascular health status of older adults with and without low back and leg pain. The study includes 1 visit lasting a total of 2 hours. Research includes blood vessel imaging, cholesterol levels and 24-hour blood pressure monitoring.
Contact Please contact Delaware Spine Studies at (302) 831-7142 at the University of Delaware to inquire about this opportunity.


Study – Menopause
Title How does diet and physical activity impact your health? Will eating grapes help women with menopause-related health conditions?
Recruitment Recruiting (Kristina Davis)
Description The University of Delaware Chai Nutrition and Health Laboratory is inviting women who are 1 to 5 years postmenopausal (approximately 40 to 60 years old) and not undergoing hormone therapy to participate in two related studies. The first study is to learn about how diet and physical activity impact menopause-related health conditions. The second study (GRAPE study) will determine if eating grapes can help women with menopause-related health conditions (i.e. brain and cardiovascular). Participants will be compensated for their time.
Contact If you would like to learn more about and participate in these studies, please call 302-831-7218 or email
Neuromotor Disorders


Study – Neuromotor Disorders
Title START-Play Program for Infants with Neuromotor Disorders
Recruitment Recruiting (Michele Lobo)
Description Evaluate the efficacy of “Sitting Together and Reaching to Play” (START-Play) intervention that targets sitting, reaching, and motor-based problem solving to improve development and readiness to learn in infants with motor delays.
Inclusion criteria Infant must be 7 to 16 months and have gross motor delays. Infant must be able to sit propped up for at least three seconds.
Parkinson's Disease
Parkinson’s Disease I
Title Step Synchronized Vibration to Improve Walking of Patients with Parkinson’s Disease.
Recruitment Recruiting (Ingrid Pretzer-Aboff)
Study Results No Results Available
Conditions Parkinson’s Disease
Interventions Sensory input device to stabilize walking and gait
Description/URL This study looks at the effects of vibratory feedback and other external cuing on people with PD who experience freezing of gait. Freezing of gait is the feeling that one’s foot is stuck to the ground.


Parkinson’s Disease II
Title Impact of Parkinson’s Telehealth Care Center on People Living with Parkinson’s Disease and their family caregiver
Recruitment Recruiting (Ingrid Pretzer-Aboff)
Description We are investigating the impact of the Nurse Managed Telehealth Parkinson’s Clinic on the function, physical activity levels, mood, health and quality of lives of people living with PD, and mood and quality of life of the caregivers who utilize the clinic. This study also offers a unique opportunity to track the effects of Parkinson’s disease on the patient and their caregiver over time. This is a longitudinal study that will involve data collection every three months for one year and then every 6 months for three years.
Inclusion criteria

PD Patients: People whose age is 21 and older who are diagnosed with Parkinson’s disease or Parkinsonism by a health care provider will be eligible for admission into this study.

Caregivers: Eligible if they are identified by the PD patient as their primary caregiver.

Exclusion criteria

PD patients: Excluded from the study if they are not able to communicate or understand English. Or, they are unable to follow directions by the investigative team, or physically cannot participate in the physical performance tests. This may be a person in the very advanced stage of Parkinson’s disease, stage V on the Hoehn & Yahr scale.

Caregivers: Those are unable to understand verbal or written English.


Pediatric mobility


Pediatric Mobility I
Recruitment Not yet recruiting (Michelle Lobo)
Study Results No Results Available
Conditions Upper Extremity Dysfunction
Interventions Device: Movement Enhancing Device


Pediatric Mobility II
Title “Watch Your Baby Grow” Study
Recruitment Recruiting (Cole Galloway)
Study Results No Results Available
Conditions Growth|Energy Balance
Interventions Other: Type of Formula
Shoulder and Elbow


Study – Shoulder and Elbow
Title Biomechanical adaptations to the shoulder and elbow in youth and collegiate overhead athletes
Recruitment Recruiting (Aaron Struminger)
Description To determine why overhead sports cause shoulder and elbow changes in youth and adult athletes. We also hope to find the link between these changes and pain.
Inclusion Criteria 11 to 14 year old athletes who participate in baseball, softball, or tennis. 18 to 25 year old college athletes participating in those sports are also welcome to participate.
Exclusion Criteria You should not participate in this study if you have undergone shoulder or elbow surgery within the last year or have been diagnosed with a neurological/muscular disorder that prevents normal development.
STAR Quit (smoking cessation program at UD)


Study – Smoking Cessation
Title STAR Quit: Examination of Sleep, Smoking Cessation and Cardiovascular Health
Recruitment Study phone line: 302-831-0989 or
Description Researchers with the Center of Biomedical Research Excellence in Cardiovascular Health at the University of Delaware are currently recruiting smokers age 18-65 years who would like to quit. Eligible smokers will receive 15-weeks of free treatment that includes 6 individual smoking cessation counseling sessions, and the quit smoking medication, Chantix.
Inclusion Criteria You may be eligible to participate if you are between the ages of 18 and 65 years old, smoke 8 or more cigarettes per day, are able to provide written informed consent in English and would like to quit within the next month.
Title Stroke Rehabilitation Studies
Recruitment Recruiting (Jennifer Marmon)
Study Results No Results Available
Conditions Stroke
Description The stroke research team includes a number of investigators and is recruiting for a variety of different studies, including investigations of: sensory and motor recovery of arm and leg function, walking and balance recovery, motor learning, and the use of non-invasive brain stimulation to enhance rehabilitation post-stroke. These range from single session evaluations to multiple week interventions. Inclusion criteria and requirements differ across studies.
Traumatic Brain Injury


Study – Traumatic Brain Injury
Title Use of an Immersive Environment to Promote Recovery in Traumatic Brain Injury (TBI)
Recruitment Recruiting (Devina Kumar)
Purpose To determine whether rehabilitation therapy can be done in an immersive environment, where social, physical and cognitive impairments are addressed collectively while working in a real life environment of the Go Baby Go café.
Who can participate Moderate to severe TBI survivors between 18 to 85 years of age who are willing to have 2 hour therapy sessions, 3 times/week for at least 1 month (up to 2 months maximum) in the Go Baby Go Café at STAR campus in Newark, Delaware.
 What the study will involve In addition to the therapy in the café, 6 evaluation sessions will be conducted over 2 months. Different test measures and questionnaire would be completed by the participant at STAR campus.